翼状胬肉切除联合三种应用丝裂霉素C的方法比较

A randomizad trial compering three procedures of mitomycin C application in excision of primary pterygium

本文观察翼状胬肉手术三种应用丝裂霉素Ｃ的方法对防止术后翼状胬肉复发的作用，采用随机分组方法对８３例１１２眼原发性翼状胬肉进行病例对照研究。丝裂霉素Ｃ的应用方法分别为术中应用（０．４ｍｇ／ｍｌ），术后一周内应用及手术一周后应用（０．２ｍｇ／ｍｌ）。结果：术中应用丝裂霉素Ｃ组翼状胬肉复发率为８．３％，术后一周内应用组复发率为１６．１％，手术一周后应用组为２０．７％，三组间的复发率无统计学差异，对照组为３２．１％，与治疗组比较具有明显统计学差异。术后一周内应用丝裂霉素组角膜创面愈合延迟。结论：翼状胬肉切除术中或术后应用丝裂霉素Ｃ可防止术后复发。术中应用丝裂霉素Ｃ方法简单，不影响角膜创面的愈合。

o invest the rate of recurrence after bare sclera excision of primary pterygia followed by three procedures of Mitomycin C application.A prospective clinical trial of 83 patients (112 eye) were assign randomly to four groups.19 patients as control.20 received Mitomycin C during operation,22 received Mitomycin C for one week after surgery and 22 received Mitomycin C one week post operatively.The recurrence rate in the four groups were 32 1%,8 3%,16 1% and 20 7%,respectively after mean follow up of 8 7 months.Delayed heal in cornea wound was happened in patients who received Mitomycin C after surgery,Each procedure of Mitomycin C application can prevent the recurrence effectively,Receiving Mitomycin C during surgery is a very simple and effective method.