Perkin脂环型化合物的合成

Synthesis of Perkin′s Aliphatic Cyclocompounds: Reactions of Diethyl Malonate and Tetraethyl 1,1,2,2 Ethanetetracarboxylates with α,ω dibromoalkanes

在金属钠的存在下，通过１，１，２，２－乙烷四羧酸四乙酯与α，ω－二溴代烷反应顺利地合成了１，１，２，２－环烷四羧酸四乙酯（Ｉａ－ｃ）．对Ｐｅｒｋｉｎ脂环型化合物的合成方法进行了改进．

Tetraethyl 1,1,2,2 cyclioalkanetetracarboxylates can be easily prepared from tetraethyl ethanetetracarboxylates and α,ω dibromoalkanes in the presence of sodium ethoxide,and also from the cyclization of tetraethyl α,α,ω,ω alkanetetraesters prepared from diethyl malonate and α,ω dibromoalkanes.