摘要
The fluorescence spectral titrations have been performed in phosphate buffer solution (pH 7 2) at room temperature to give the stability constants for inclusion complexation of a series of chemically modified β cyclodextrins bearing aromatic groups with adamantanol. The molecular recognition mechanism is discussed from the viewpoint of the structural factors, electron effect of the substitutent groups and the size and chain length of the fluorophore. The results indicate that the complex stability of the cyclodextrin derivatives bearing a positively charged pyridinio moiety can be enhanced by the electrostatic interaction between the host cyclodextrins and the adamantanol guest and the microenvironment change plays a crucial role in the inclusion complexation.
The fluorescence spectral titrations have been performed in phosphate buffer solution (pH 7 2) at room temperature to give the stability constants for inclusion complexation of a series of chemically modified β cyclodextrins bearing aromatic groups with adamantanol. The molecular recognition mechanism is discussed from the viewpoint of the structural factors, electron effect of the substitutent groups and the size and chain length of the fluorophore. The results indicate that the complex stability of the cyclodextrin derivatives bearing a positively charged pyridinio moiety can be enhanced by the electrostatic interaction between the host cyclodextrins and the adamantanol guest and the microenvironment change plays a crucial role in the inclusion complexation.
基金
ThisworkwassupportedbytheNationalOutstandingYouthFund (GrantNo .2 96 2 5 2 0 3)
Trans CenturyTrainingProgrammeFoundationfortheTalentsoftheStateEducationCommissionofChina ([1995 ]4 )
andtheNationalNaturalScienceFoundationofChina (GrantNo .2 96 72 0
