摘要
目的对16例晚期食管癌导致的食管管腔梗阻患者行内镜下缓释5-氟尿嘧啶(5-FU)粒子植入治疗,观察其缓解梗阻的疗效。方法胃镜下对食管癌梗阻部结节及浸润处多点或密集型植入5-FU缓释粒子。结果 16例患者施行粒子植入治疗后,缓解梗阻有效14例,无效2例,总有效率87.5%。内镜下缓释5-FU粒子植入治疗未发生出血、穿孔等并发症及恶心、呕吐、腹痛、发热等不良反应,肝、肾功能及血常规检查未见异常。结论内镜下缓释5-FU粒子植入治疗是缓解晚期食管癌患者梗阻症状安全、有效的方法。
Objective To observe the efficacy of endoscopic implantation of slow-releasing 5-fluorouracil （5-FU） in relieving esophagus obstruction due to locally-advance carcinoma. Methods A total of 16 advanced esophagus cancer patients were enrolled into this study. During the endoscopy procedure, slow-releasing 5-FU agent was implanted compactly into the infiltrated tumor lesion. Results After endoscopy procedure, the numbers of patients with effective resuits in relieving symptom were 14, with overall response rate of 87.5%. Hemorrhage, perforation, nausea, vomit, abdominal pain, fever were not observed. Parameters of hepato-renal function and complete blood count were stable after implantation. Conclusion Endoscopic implantation of slow-releasing 5-fluorouracil is safe and effective in relieving ma- lignant esophagus obstruction.
出处
《胃肠病学和肝病学杂志》
CAS
2011年第10期907-908,共2页
Chinese Journal of Gastroenterology and Hepatology
关键词
食管癌
5-氟尿嘧啶
内镜植入
Esophagus carcinoma
5-fluorouraeil
Endoscopic implantation
