围手术期静脉营养对老年大肠癌患者T淋巴细胞亚群的影响

Effects of perioperative parenteral nutrition on T-lymophocyte subsets in aged patients with colorectal cancer

目的：探讨静脉营养支持对老年大肠癌患者免疫功能的影响。方法：以OKT系列单克隆抗体，采用直接SPA菌体花环法测定老年大肠癌患者静脉营养支持前后外周血T淋巴细胞及亚群分布的变化。结果：术前或术后静脉营养支持使患者Th，Th／TS比值显著性提高，术后静脉营养支持使Th亦显著性提高，而Ts则无显著性变化。结论：我们认为围手术或静脉营养支持能够提高老年大肠癌患者的细胞免疫功能，促进由于手术造成的免疫损害的恢复，但不能消除肿瘤产生的免疫抑制作用。

objective:To elucidate the effects of parenteral nutrition support on immunocompetence in aged patients with colorectal cancer. Methods:We administrated nutrition support to the aged patients with colorectal cancer. Changes of peripheral blood T-lwnphocyte subsets (OKT series monoclonal antithey, the method of Drect Rosette Test of staphylococcus aureus)were monitored before and after nutrition support. Results:The results showed that pre or postoperative parenteral nutrition made the T-help and T-help/Tsuppressor ratio significantly increased. The total T-lmpphocytes count might also increas potsoperative parenteral nutrition support. T-suppressor remained unchanged no matter whether nutritional support was given. Conclusion: We believed that parenteral nutrition support could improve the immunocompetence of aged colorectal cancer patients to some extent and promote the restoration of immune depression caused by operation, but it could not eliminate the effects of immune depressing factors produced by the tumor.