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血必净对恙虫病患者多器官功能障碍的保护作用及机制 被引量:3

Protective effects of Xuebijing on multiple organ dysfunction syndrome and its mechanism in tsutsugamushi disease
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摘要 目的探讨血必净注射液对恙虫病患者多器官功能障碍的保护作用及其机制。方法将19例恙虫病患者随机分为常规治疗组(9例)和血必净治疗组(10例),两组患者均给予氯霉素和左氧氟沙星治疗,血必净治疗组在此基础上加用血必净注射液。观察两组治疗前和治疗后第5天血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、内毒素(LPS)、肿瘤坏死因子(TNF)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、氧合指数(PaO2/FiO2)、凝血酶原时间(PT)、部分凝血酶原时间(APTT)、血小板(PLT)、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分的水平变化。结果常规治疗和血必净治疗组的治愈率分别为22.22%、60%(P<0.05)。血必净治疗5d后,AST、ALT分别从(102.5±24.5)U/L、(101.3±23.4)U/L下降为(43.3±10.2)U/L、(39.2±6.5)U/L(P<0.05),PLT、PaO2/FiO2分别从(98.2±42.2)×109/L、(225.0±19.0)mmHg升高为(278.3±15.6)×109/L、(352.0±6.0)mmHg(P<0.05),APACHEⅡ显著下降(P<0.01);LPS、INF、IL-6、IL-8显著降低(P<0.05)。结论血必净注射液可以提高对恙虫病患者的治愈率,对多器官功能损害具有保护作用;其机制为主要通过减少炎症介质分泌来实现。 Objective To investigate the protective effects and its mechanism of Xuebijing injection on multiple organ dysfunction syndrome in tsutsugamushi disease. Methods 19 patients with tsutsugamushi disease were randomly divided into the routine treatment group (9 cases) and Xuebijing plus routine treatment group (10 cases). Chloramphenicol and levofloxacin were used in both groups. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipopolysaccharide (LPS), tumor necrosis factor (TNF), interleukin-6 (IL-6),interleukin-8 (IL-8), oxygenation index (PaO2/FiO2), prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet (PLT), and acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) level were measured before and 5 days after treatment. Results After 5 days of treatment, the levels of AST, ALT, TNF, IL-6, IL-8 and APACHEⅡ were decreased, while the levels of PLT and PaO2/FiO2 were increased significantly in the Xuebijing plus routine treatment group compared with the routine treatment group (P0.05,P0.01). Conclusion Rate of cure were increased and there were protective effcects of Xuebijing on the MODS in tsutsugamushi disease, and it could reduce the secretion of inflammatory mediators.
出处 《热带医学杂志》 CAS 2011年第10期1151-1152,1189,共3页 Journal of Tropical Medicine
关键词 恙虫病 多器官功能障碍综合征 血必净注射液 内毒素 肿瘤坏死因子 tsutsugamushi disease multiple organ dysfunction syndrome Xuebijing injection lipopolysaccharide tumor necrosis factor
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