心包原发性恶性间皮瘤的临床特点及病理观察

An analysis of primary malignant pericardial mesothelioma

目的:了解心包原发性恶性间皮瘤(primary malignant pericardial mesothelioma,PMPM)的临床病理特点。方法:收集2例PMPM患者的临床资料。切除组织HE染色光镜观察,免疫组织化学做CKp、CK18、EMA、MC、Vimentin、CEA、Calretinin、TTF1、Tg标记。结果:2例PMPM是以上皮细胞为主型,呈乳头状和腺管样排列。免疫组织化学标记瘤组织CKp、CK18、Vimentin、Calretinin阳性。MC例1阳性,例2阴性,EMA例1阴性,例2阳性。临床改变似心包炎和心包积液。结论:恶性心包间皮瘤临床改变似心包炎,只有病理检查才能确诊。

Objective：To investigate the clinicopathological features of primary malignant pericardial mesothelioma.Methods： By means of histological,and immunohistochemical studies,the clinical and pathological features of two cases of primary pericardial malignant mesothelioma were analyzed.Results： Patients of two cases were 38 and 60 years old.The tumors were located in the pericardial,and involved the wall of pericardial.Immunohistochemical expression of cytokeratin AE1/AE3,cytokeratin 18,Vimentin,epithelial membrane antigen,Calretinin were positive in both cases,mesothelial cell was positive in case 1 and negative in case 2.Conclusion： Primary malignant pericardial mesothelioma is a rare tumor.The diagnosis was based on histological and immunohistochemical staining.