乌司他丁对食管癌患者术后并发症的预防作用

Preventive effect of ulinastatin on postoperative complications in esophagectomy patients

目的:观察乌司他丁对食管癌患者术后并发症的预防作用。方法:选择食管癌患者60例,随机分为对照组和乌司他丁治疗组。乌司他丁组在术前3天至术后3天,每天给予乌司他丁20万U,观察术后并发症的发生率、ICU时间以及住院时间等指标。结果:乌司他丁组术后并发症发生率明显低于对照组,以肺部并发症最有意义(P<0.05),且ICU留置时间明显低于对照组(P<0.05)。结论:对食管癌患者应用乌斯他丁,能明显减少术后并发症,而且缩短ICU留置时间,值得临床推广应用。

Objective：To evaluate the potential efficacy of preventive effect of ulinastatin on postoperative complications in esophagectomy patients.Methods： Sixty patients with esophageal cancer were preoperatively allocated at random into two equal groups.Ulinastatin was intravenously administered to the treatment group（U）at a dose of 200000 U every 24h from 3 days pre-operation until 3 days post-operation,whereas the control group（C）received placebo.Clinical courses of patients in the two groups were compared.Results： The rate of postoperative complications and the duration of ICU stay was significantly lower in the U group（P0.05）.Conclusion： Ulinastatin is worth using in clinic course for its preventive effect on postoperative complications and decrease of the ICU stay in esophagectomy patients.