缺氧诱导因子-1在胰腺癌组织中的表达及临床意义

Significance and expression of HIF-1α in pancreatic carcinoma

目的:探讨缺氧诱导因子(HIF-1α)在胰腺癌组织中的表达及其临床意义。方法:应用免疫组化技术检测HIF-1α蛋白在48例胰腺癌组织和5例正常胰腺组织中的表达情况,并分析其与临床病理因素及预后之间的关系。结果:HIF-1α蛋白在48例胰腺癌组织中的阳性表达率为52.1%(25/48),而在5例正常胰腺组织中均未见表达,两者间差异有统计学意义(P<0.01)。HIF-1α表达与肿瘤体积(P=0.015)及TNM分期呈正相关(P=0.021),与预后呈负相关(10.4%vs 4.0%,P=0.027);而与胰腺癌的部位、病理分级等无关(P>0.05)。结论:HIF-1α在胰腺癌的发生发展过程中起着重要作用,可作为判断胰腺癌预后的有用指标。

Objective：To detect the expression of hypoxia inducible factor-1α（HIF-1α）in pancreatic carcinoma and investigate the relationship with clinicopathologic features and prognosis of pancreatic carcinoma.Methods： Immunohistochemistry staining was used to detect expression of HIF-1α in 48 cases of pancreatic carcinomas and 5 cases of normal pancreases tissues.The relationship and clinical significance of HIF-1α expression in pancreatic cancer were analyzed.Results： The positivity rate of HIF-1α in pancreatic carcinomas was 52.1%（25/48）.No HIF-1α expression was detected in 5 cases of normal pancreases tissues.The positivity rate of HIF-1α in pancreatic carcinomas was significantly higher than that in normal pancreases tissues（P0.01）.HIF-1α protein expression was closely correlated with tumor size（P=0.015）and TNM stage（P=0.021）,and was negative correlated with prognosis（10.4% vs 4.0%,P=0.027）,rather than position and pathological grading.Conclusion： High expression of HIF-1α plays a considerable role in development of pancreatic carcinoma.HIF-1α may be a useful marker for evaluating prognosis in pancreatic cancer.