病毒性乙型肝炎与PHSAR相关性探讨

RELATIONSHIP BETWEEN HEPATITIS B AND POLYHUMAN SERUM ALBUMIN RECEPTOR

采用ELISA法对1344例临床血清标本进行乙肝病毒(HBV)标志物和多聚人血清白蛋白受体(PHSAR)检测,在HBV标志物阳性者314例中,PHSAR阳性107例占34.1％,在HBsAg、HBeAg、抗-HBc三者同时阳性的81例中,PHSAR阳性54例占66.67％;在HBsAg、抗-HBe、抗-HBc同时阳性的125例中,PHSAR阳性15例占12.0％;在HBsAg、抗-HBc阳性的67例中,PHSAR阳性25例占37.3％;而在HBsAg阴性1030例标本中PHSAR均为阴性,提示PHSAR可作为HBV感染急性期及病毒复制的标志之一,其存在表明HBV在体内复制活跃,传染性较强。

Hepatitis B virus (HBV) marker and polyhuman serum albumin receptor (PHSAR) were detected by ELIAS in 1344 patients. Of 314 ones with HBV marker positive, 107 ones with PHSAR positive (34. 4%). Of the 812 ones with HBsAg, HBcAg and and - HBc positive, 54 ones with PHSAR positive (66. 6%). Of 125 ones with HBsAg, anti -HBe and ami -HBc positive, 15 ones with PHSAR potitive (12.0%). Of 67 ones with HBsAg and anti-HBc positive, 25 ones with PHSAR posi-tive(37. 3%). But PHSAR was positive in 1030 ones with HBsAg negative. It was indicated that PHSAR might become a marker of the acute stage of HBV infection and virus replication. Its existence showed that HBV was replicating lively in vivo and its infectivity was high.