摘要
DTPA was covalently conjugated to the copolymer of L-lysine and L-tyrosine,then transchelated with Gd-EDTA,the resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose or methyl lactobionyloxyacetate to give PLT(Gd-DTPA)with galactose moiety as liver-targeting group.These macromolecular MRI contrast agents were characterized by means of FT-IR,ICP-AES,elementary analyses and UV-Vis spectrophotometry.Their in vitro relaxivity and liver targeting property in mice were also investigated.
DTPA was covalently conjugated to the copolymer of L-lysine and L-tyrosine,then transchelated with Gd-EDTA,the resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose or methyl lactobionyloxyacetate to give PLT(Gd-DTPA)with galactose moiety as liver-targeting group.These macromolecular MRI contrast agents were characterized by means of FT-IR,ICP-AES,elementary analyses and UV-Vis spectrophotometry.Their in vitro relaxivity and liver targeting property in mice were also investigated.
