川芎对家兔膝关节骨性关节炎骨内压的影响

Effect on Intraosseous Pressure of Osteoarthritis in the Rabbit Knee with Ligusticum Wafllichii

按照Langenskiold的方法制成家兔膝关节骨性关节炎模型,观察20％川芎注射液对其胫骨上端骨内压的影响。结果表明20％川芎注射液具有显著的持续降低骨内高压的作用。本实验为临床上应用川芎治疗骨性关节炎,降低其骨内高压,解除骨关节疼痛尤其休息痛提供了实验依据。

The osteoanhritis(OA) models in the rabbits knee were produced as Langenskiold's method, studying effect on intraosseous pressure (IOP) of the proximal tibia in the models with 20 percent Ligusticum Wallichii(LW) injection. The results show that LW injectio has evident effects on treatment of intraossous hypertension, and the effects can Last rather Long period of time. This study has provided an experiment basis for applying LW to the clinical treatment of OA, Lowering intraosseous hypertension and relieving the pain, especially rest pain, in the bone and joint.