摘要
The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR.
The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR.
