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结核分枝杆菌TB10.4抗原的分子生物学特性研究进展 被引量：1

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摘要 结核病（tuberculosis,TB）这种古老的慢性人兽共患病,4千多年前就已流行于全球,而且至今仍危胁着全球近1/3人口的健康[1]。自1921年诞生且是当前唯一可行的卡介苗（Bacillus Calmette-Gufirin，BCG），是至今接种人数最多、使用范围最广的疫苗之一，但该疫苗的免疫保护效果并不理想，
作者 欧珍 陈祥 孟闯 焦新安
机构地区 扬州大学
出处 《中国人兽共患病学报》 CAS CSCD 北大核心 2011年第11期1031-1034,共4页 Chinese Journal of Zoonoses
基金 “973”项目(2012CB518805) 国家科技重大专项(2008ZX10003-010) 国家公益性行业科研专项(200903027)和教育部创新团队联合资助
关键词 分子生物学特性 结核分枝杆菌 抗原 免疫保护效果 人兽共患病 接种人数 结核病 卡介苗
分类号 R378.9 [医药卫生—病原生物学]
  • 相关文献

参考文献23

  • 1Stead W. The origin and erratic global spread of tuberculosis: how the past explains the present and is the key to the future[J]. Clin Chest Med, 1997, 18(1): 65-77.
  • 2Sorensen Air, Nagai S, Houen G, et al. Purification and characterization of a low-molecular-mass T-cell antigen secreted by My cobacterium tuberculosis[J]. Infect Immun, 1995, 63(5) : 1710- 1717.
  • 3Skjot RL, Oettinger T, Rosenkrands I, et al. Comparative eval uation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens[J]. Infect Immun, 2000, 68 ( 1 ) : 214-220.
  • 4Rindi L, Lari N, Garzelli C. Genes of Mycobacterium tuberculo- sis H37Rv downregulated in the attenuated strain H37Ra are re stricted to M. tuberculosis complex species[J]. New Microbiol, 2001, 24(3): 289 294.
  • 5Abdallah AM, Gey Van Pittius NC, Champion PA, et al. Type VII secretionmycobacteria show the way[J]. Nat Rev Microbi ol, 2007, 5(11): 883-891.
  • 6Siegrist MS, Unnikrishnan M, McConnell MJ, et al. Mycobac- terial Esx 3 is required for mycobactin-mediated iron acquisition [J]. ProcNatlAcadSciUSA, 2009, 106(44): 18792-18797.
  • 7Maciag A, Dainese E, Rodriguez GM, et al. Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon[J]. J Bacteriol, 2007, 189(3):730-740.
  • 8Rodriguez GM, Voskuil MI, Gold B, et al. IdeR, an essential gene in Mycobacterium tuberculosis : role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress re- sponse[J]. Infect Immun, 2002, 70(7): 3371-3381.
  • 9Maciag A, Piazza A, Riccardi G, et al. Transcriptional analysis of ESAT 6 cluster 3 in Mycobacterium smegmatis[J]. BMC Microbiol, 2009, 9: 48.
  • 10Lightbody KL, Ilghari D, Waters LC, et al. Molecular features governing the stability and specificity of functional complex formation by Mycobacteriurn tuberculosis CFP 10/ESAT-6 family proteins[J].J BiolChem, 2008, 283(25):17681-17690.

同被引文献22

  • 1STEAD W.The origin and erratic global spread of tuberculosis:how the past explains the present and is the key to the future [J].Clin Chest Med,1997,18(1):65-77.
  • 2ANDERSEN P,DOHERTY T M.The success and failure of BCG-implications for a novel tuberculosis vaccine [J].Nat Rev Microbiol,2005,3:656-662.
  • 3MACIAG A,DAINESE E,RODRIGUEZ G M,et al.Global analysis of the Mycobacterium tuberculosis Zur (FurB) regulon [J].J Bacteriol,2007,189(3):730-740.
  • 4HERVAS S S,MAJLESSI L,SIMSOVA M,et al.High frequency of CD4+ T cells specific for the TB10.4 pro-tein correlates with protection against Mycobacterium tuberculosis infection [J].Infect Immun,2006,74(6):3396-3407.
  • 5STEFAN H E,KAUFMANN G H,PAUL-HENRI L.New vaccines for tuberculosis [J].Lancet,2010,375(9731):2110-2119.
  • 6DE JONGE M I,PEHAU A G,FRETZ M M,et al.ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity [J].J Bacteriol,2007,189(16):6028-6034.
  • 7BEKMURZAYEVA A,SYPABEKOVA M,KANAYEVA D.Tuberculosis diagnosis using immunodominant,secreted antigens of Mycobacterium tuberculosis [J].Tuberculosis (Edinb),2013,93(4):381-388.
  • 8HERVAS S S,MAJLESS L,SIMSOVA M,et al.High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection [J].Infect Immun,2006,74(6):3396-3407.
  • 9SKJOT R L,OETTINGER T,ROSENKRANDS I,et al.Comparative evaluation of low-molecular'mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens [J],Infect Immun,2000,68(1):214-220.
  • 10ZUNIGA J,TORRES,GARCIA D,SANTOS M T,et al.Cellular and humoral mechanisms involved in the con-trol of tuberculosis [J],Clin Dev Immunol,2012:193923.

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二级引证文献6

中国人兽共患病学报
2011年 第11期

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