游离前列腺与总前列腺特异性抗原比值在前列腺癌诊断中的价值

Diagnostic value of free- to- total PSA in prostate cancer

目的 :探讨游离前列腺特异性抗原 ( FPSA)与总前列腺特异性抗原 ( TPSA)比值在鉴别前列腺癌 ( PC)和良性前列腺增生 ( BPH)中的作用。 方法 :采用放射免疫法对 12例 PC和 30例 BPH患者的血清 FPSA和 TPSA进行测定。 结果 :FPSA与 TPSA比值在 PC和 BPH中差异非常显著 ( P<0 .0 0 1) ,分别为 9.85%和 2 0 .12 %。当二者比值的界值 <0 .15时 ,其 PC诊断的敏感性 (取 PSA<4 ng/ ml为界值 )为 92 % ,特异性由 60 %提高至 80 %。 结论 :二者比值 <0 .15时提高了 TPSA在 PC和 BPH中的鉴别诊断 ,可早期发现

Objectives:To determine whether free- to- total PSA(FTPSA) offers a better discrimination than TPSA alone in the detection of patients with prostate cancer(PC) and those with benign prostatic hyperplasia(BPH) . Methods:FPSA and TPSA were deter- mined using radioimmunoassay in1 2 patients with PC and30 patients with BPH. Results: Patients with PC had a lower percentage of FTPSA(9.85 % ) than those with BPH(2 0 .1 2 % ) (P<0 .0 0 1 ) .By using cutoff levels of <0 .1 5 of FTPSA and<4ng/ ml of TPSA,sensitivity for both PC and BPH were 92 % ,and the specificity was improved from 6 0 % to 80 % . Con- clusions:The results favor the combination of FTPSA and FTPSA in discriminating patients with early,potentially curable PC from patients with BPH.