P53和C-erbB-2基因蛋白在乳腺癌中表达的研究

RESEARCH ON THE EXPRESSION OF P53 AND C- erbB- 2 ONCOGENE PROTEIN IN BREAST CANCER

利用SP免疫组织化学方法,检测了我区106例乳腺癌组织中P53和C-erbB-2基因蛋白,结果表明,它们的阳性率分别为43.4％和54.77％,阳性表达与病理学类型和年龄相关性不明显。淋巴结转移组P53和C-erbB-2阳性率分别为60.8％和75.36％,明显高于无淋巴结转移组。本实验提示,对乳腺癌患者进P53和C-erbB-2检测。

P53 and C - erbB - 2 oncogene protein were deter mined with immunohistochemistry method (SP method) in 106 cases of breast cancer. The results showed that the positive rates of P53 and C - erhB-2 were 43.4% and 54.77 % . Positive rates of P53 and C - erbB - 2 .were related to pathologic tissue type and age were not obvious correlation. The positive rate of the armpit lymph node metastasis (P53 and C - erbB 2 were 60.87% and 75.36% ) was higher than the not have lymph node metastasis. The study indicated that assaying levels of P53 and C - erbB - 2 of breast cancer are of great value for iistimating prognosis.