摘要
应用ｓ－ｐ免疫组化法对４１例广西籍小肝癌标本进行ｃ－ｅｒｂＢ－２和ｐ５３检测，表达率分别为２６．８％和３６．６％，ｃ－ｅｒｂＢ－２和ｐ５３表达无相关性，其表达率与肝细胞癌的病理组织学类型、患者预后均无明显关系（Ｐ＞０．０５）。提出小肝癌的发展、转移可能是涉及多种癌基因的共同过程，癌基因ｃ－ｅｒｂＢ－２和抗癌基因ｐ５３在其中可能并不起主导作用，因此，仅根据ｃ－ｅｒｂＢ－２表达和／或根据ｐ５３突变率来估计小肝癌术后患者的预后会有一定局限性，须参照更多指标综合分析才较为可靠。
The expression of c erbB 2 and p53 in 41 patients born in Guangxi with small hepatocellular carcinoma was found 26 8% and 36 6% respectively examined with S P immunohistochemical technique The results showed that there was no significant relationship between the c erbB 2 and p53 expression statistically, also between the expression of both and histopathological classification and prognosis for small hepatocellular carcinoma ( p >0 05) The progression and metastasis of small hepatocellular carcinoma might be a common progress involved with multiple oncogenes and c erbB 2 and p53 could not play mainrole in the progress Therefore, it should refer to a number of indicators to predict the prognosis of patients with hepatocelular carcinoma but not only to the expression of c erbB 2 and p53
出处
《华夏医学》
CAS
1997年第1期8-10,共3页
Acta Medicinae Sinica
