乙型重症肝炎HDV重叠感染的临床意义

Clinical Implications of Severe Hepatitis B SuprerInfection of HDV

对８５例乙型重症肝炎患者血清进行了丁型肝炎病毒标志物（ＨＤＶＭ）及肝功能检测。结果ＨＤＶＭ阳性率为２９．４１％，表明桂林地区乙型重症肝炎患者中ＨＤＶ感染率较高；乙型重症肝炎ＨＤＶ重叠感染后肝功能损害程度明显加重，重症肝炎主要并发症发生率及死亡率明显增高，提示ＨＤＶ感染可导致乙型重症肝炎临床病情加重。同时发现乙型重症肝炎ＨＤＶ重叠感染后乙型肝炎病毒复制标志阳性率低。

The serologic marker of HDV (HDVm) and the function of liver were assayed in 85 patients with severe hepatitis B It was found that the positive rate of HDVm was 29 41% The results showed that there was a higher infection of HDV in patients with severe hepatitis B in Guilin City and Guilin region, much more damaging to the liver and there were higher main complications and mortality in patients with severe hepatitis B superinfection of HDV It indicated that the infection of HDV could make severe hepatitis B worse It was also found that there was a lower positive rate of HBV replication markers in severe hepatitis B superinfection of HDV.