溶栓治疗急性心肌梗塞中白细胞计数与心肌酶峰值的关系

The Relationship Between WBC Count and the Peak Value of CK.CKMB in Thrombolytic Treatment for Acute Myocardial Infarction

为探讨急性心肌梗塞（ＡＭＩ）溶栓治疗对心肌酶峰值的影响及白细胞计数（ＷＢＣ）与ＡＭＩ的关系，对２１１例ＡＭＩ患者随机分成尿激酶（ＵＫ）治疗组与常规治疗对照组，测定静脉血ＷＢＣ及监测心肌酶。结果显示：常规治疗患者ＷＢＣ增高组（＞１０×１０９／Ｌ）心肌酶（ＣＫ．ＣＫＭＢ）峰值明显高于ＷＢＣ正常组（≤１０×１０９／Ｌ）（Ｐ＜０．００１）；溶栓治疗患者ＷＢＣ增高组与ＷＢＣ正常组心肌酶峰值无显著差异（Ｐ＞０．０５）。溶栓组心肌酶峰值显著高于对照组（Ｐ＜０．０１）。结论：非溶栓治疗患者，ＷＢＣ升高是心肌坏死程度指标。溶栓治疗患者心肌酶峰值增高是心肌再灌注特有指标之一。

In order to approach the influence of thrombolytic treatment for acute myocardial infarction(AMI)on the peak value of CK.CKMB and the relationship between WBC count and AMI,211 cases of AMI were divided randomly into urokinasetreated group and routinetreated control group,and their WBC in venous blood were determined and their CK.CKMB,monitored.The results showed that the peak value of CK.CKMB of patients with routine treatment in WBC increased group(>10×109/L)was markedly higher than that in WBCnormal group (≤10×109/L)(P<0.01);there was no marked difference(P>0.05)of peak value of CK.CKMB in WBCnormal group of patients with thrombolytic treatment.The peak value of CK.CKMB in the group of thrombolytic treatment was markedly higher than that in control group (P<0.01).The conclusion is that increase of WBC is the indicator of degree of myocardial necrosis of patients with unthrombolytic treatment.The increase of peak value of CK.CKMB of patients with thrombolytic treatment is one of the characteristic indicators of myocardial reperfusion.Thrombolytic treatment blocked the myocardial damage action of WBC in AMI.