胰岛素抵抗与老年冠心病关系探讨

Study on the Relationship Between Insulin Resistance and Coronary Heart Disease in the Aged Persons

目的：探讨胰岛素抵抗（ＩＲ）与老年冠心病的关系；方法：对４８例老年冠心病患者及４５例老年非冠心病患者进行空腹血胰岛素、血糖、总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白（ＨＤＬ）、血管紧张素（Ａｎｇ）Ⅰ、Ⅱ检测及对比分析。结果：老年冠心病组胰岛素、ＴＧ和ＡｎｇⅡ显著高于非冠心病组（分别为Ｐ＜０．０１，Ｐ＜０．０５，Ｐ＜０．０５），冠心病组血糖、ＴＣ、ＨＤＬ和ＡｎｇⅠ与非冠心病组无明显差异（Ｐ＞０．０５）。结论：老年冠心病患者存在高胰岛素血症和ＩＲ。

Purpose:To study the relationship between insulin resistance (IR) and coronary heart disease (CHD) in the aged persons.Method:The levels of blood glucose,serum insulin,total cholesterol (TC),triglycerides(TG),high density lipoprotein(HDL),angiotensin I and angiotensinⅡin fasting condition of all the subjects including 48 aged CHD and 45 aged nonCHD were mesured and these results were compared.Results:The serum insulin,TG and angiotensinⅡlevels in the aged CHD group were higher than these in the aged nonCHD group (P<0.01,P<0.05 and P<0.05 respectively),significant difference in the blood glucose,TC,HDL and angiotensin Ⅰ(P>0.05) was found between the groups of CHD and nonCHD .Conclusion:The aged patients with CHD are associated with hyperinsulinemia and IR.