摘要
给雄性ＳＤ大鼠一次腹腔注射ＭＣＴ（野百合碱）５０ｍｇ／ｋｇ，经５周后引起肺动脉高压和右心室肥厚，左心室未见明显变化，体循环血压亦无变化。对血浆中血管活性物质ＥＴ（内皮素）、ＡＮＰ（心钠素）、ＣＧＲＰ（降钙素基因相关肽）、ｃＧＭＰ（环磷酸鸟苷）及肺组织中，ｃＧＭＰ进行放射免疫测定。结果显示，大鼠注射ＭＣＴ５周后，ＥＴ、ＡＮＰ明显升高，ＣＧＲＰ、ｃＧＭＰ降低。统计学分析结果表明肺动脉高压与以上血管活性物质的变化有一定的相关关系。
In this study,male Sprague Dawley rats received a single dose of monocrotaline(50 mg/kg ) intraperitoneally. Five weeks later,the pulmonary hypertention and the right ventricular hypertrophy occurred,The cervical arterial pressure didn't have any changes yet.Endothelin(ET),atrial natriuretic peptide(ANP),calcitonin gene related peptide(CGRP) and cyclic guanosine monophosphate(cGMP) in the plasma and cGMP in the lung tissue were examined by radioimmunoassay.The results showed that ET、ANP had a significant elevation but CGRP、cGMP lowered,and that there were some relationship between pulmonary hypertension and these vaso active substances.
出处
《新疆医科大学学报》
CAS
1997年第2期15-18,共4页
Journal of Xinjiang Medical University
关键词
野百合碱
动物模型
高血压/肺性
内皮素
心房利钠因子
降钙素基因相关肽
环磷酸鸟苷
monocrotaline
animal model
pulmonary hypertension
endothelin
atrial natriurectic peptide
calcitonin gene related peptide
cyclic guanosine monophosphate
