小儿病毒性心肌炎患者血浆心钠素的测定

Determination of Plasma Atrial Natriuretic Factor Concentration in Children with Viral Myocarditis

用放射免疫分析方法对新疆地区６０例１．５～１２岁的健康儿童和３６例４个月～１４岁的病毒性心肌炎患儿血浆心钠素（ＡＮＦ）进行研究。结果，健康儿童的血浆ＡＮＦ值为０．６２７±０．１３０ｎｇ／ｍｌ。病毒性心肌炎（急性期）患儿血浆ＡＮＦ值为０．９２６±０．４６０ｎｇ／ｍｌ，未合并心律失常者其血浆ＡＮＦ值为０．７８４±０．０９０ｎｇ／ｍｌ；合并心律失常者中，３个组的ＡＮＦ值分别为０．８１８±０．３７５ｎｇ／ｍｌ、１．０８５±０．４１０ｎｇ／ｍｌ、０．９００±０．５６６ｎｇ／ｍｌ。测定结果表明：（１）对照组无年龄性别差异。（２）病毒性心肌炎（急性期）患者血浆ＡＮＦ值显著高于对照组（Ｐ＜０．０５）。其中未合并心律失常者其血浆ＡＮＦ值也高于对照组（Ｐ＜０．０５）；合并心律失常者中，除Ⅲ组外，Ⅰ组和Ⅱ组与对照组相比，均有显著差异（Ｐ均＜０．０１）。

The concentration of plasma atrial natriuretic factor (ANF) in peripheral blood was measured by radioimmunoassay in 36 patients with viral myocarditis and 60 control children of 1.5-12 years old in Xinjiang. No difference was found between sex and age in control group. The mean plasma ANF levels for patients with myocarditis (0.926±0.460 ng/ml) was significantly higher than that in healthy children (0.627±0.130 ng/ml). Patients of viral myocarditis without arrhythmia showed an obviously higher mean ANF concentration ( 0.784 ±0.090 ng/ml), P<0.05. Those who suffered from viral myocarditiswith arrhythmia, in addition to group Ⅱ (1.085±0.410 ng/ml)(P<0.01) and group Ⅰ (0.818±0.375 ng/ml)(P<0.01), except group Ⅲ (0.900±0.556 ng/ml), also demostrated significantly high level, P<0.01. A few unreasonable results might be due to fewer patients in our series.