速避凝治疗急性脑梗塞的临床观察

The clinical Observation of Fraxiparine in the treatment of acute cerebral infarction

对23例起病在48小时内的急性脑梗塞患者随机分为治疗组和对照组,观察低分子肝素-速避凝对患者神经功能缺损恢复和部分血液学指标的影响。结果表明,治疗后神经功能缺损评分与治疗前得分差值的中位数显著高于对照组(P<0.05);治疗组治疗前后患者TT、PT、KPTT均无明显差异(P>005);血浆D—二聚体于治疗后明显升高(P<0.001),而血小板聚集功能减低(P<0.05)。说明速避凝可能通过增强体内纤溶活动、减低血小板聚集功能起到抗血栓和抗凝作用,进而可促进急性脑梗塞所致神经功能缺损恢复。

Twenty-three acute cerbral infarction patients with onset less than 48 hours were randomly divided into therapeutic and control groups , and the effects of low molecular weight heparin (Fraxiparine)on the restitution of patients' neuro-function defects and some hematolog-ical index were observed between these two groups. The results showed that scoring difference median of neuro-function defects before and after therapy is significantly higher than than in the control group; that there was no signifcant difference of TT, PT, KPTT berore and after therpy; that there was a marked increase of plasma D-Dimer after therapy .while the platelet aggregation decreased. These suggest Fraxiparine may play a role in antithrombosis and anticoagulation through enhancing fibrolysis and inhibiting platelet aggregation, which may promote the restitution of neuro -runction defects caused by acute cerebral infarction.