抑肽酶影响体外循环时BPC,GMP-140和D-二聚体的观察

Observation of Aprotinin on Platelet Count,Platelet α- granule Membrane Protein 140, D - Dimer in External Circulation

本文对大剂量抑肽酶在心脏手术中的应用价值作了临床观察。随机选择了成人二尖瓣置换术、主动脉瓣置换术和先天性心脏病患者40例,对照组和用药组各20例。检测血小板计数(BPC),血小板CMP-140及D-二聚体等指标,观察转流后手术止血时间,术后3小时和24小时心包引流量和输血量,结果表明大剂量抑肽酶可以大大缩短转流后手术止血时间,减少术后出血量和输血量。

In this study, clinical observation have been made to investigate the application value of high - dose aprotinin in cardiac surgery.40 cases of adult patients, undertaking mitral value or aortic value replacement of suffering from congentital heart disease, were randomly divided into two groups as the control group( n - 20) and the treatment group (n - 20), then assayed for platelet count( BPC), plalelet α - granule membrane protein 140 (GMP- 140)and D- Dimer.The time for stopping bleeding alter bypass, the amount of pericardium drainage and blood transfusion 3h and 24h after operation were also measured. The results indicate that high - dose apro-tinin can greatly shorten the time for stopping bleeding alter by pass bence reduce the amount of blood supply and the rate of bleeding complication.