PN对COPD急性期合并营养不良患者的营养支持效果

The effect of parenteral nutritional support on serum free amino acids in exacerbation of COPD patients with malnutrition

目的：探讨肠外营养（PN）对慢性阻塞性肺病急性加重期合并营养不良患者的治疗效果，及血清游离氨基酸在营养支持中的变化。方法：21例慢性阻塞性肺病（COPD）急性加重期合并营养不良患者随机分为两组，肠外营养组（PN组）和对照组。结果：两组患者与正常值比较皆存在广泛的血清游离氨基酸（SFAA）含量及各类组分含量显著低下（P＜0．01）。PN支持两周后，PN组的血清绝大部分游离氨基酸含量发生显著改善（P＜0．01），对照组改变不明显。结论：PN对COPD急性加重期合并营养不良患者的营养支持有效，并为临床营养提供依据及指导。

To study the effect of parenteral nutritional support on serum free amino acids in exacerbation of COPD patients with malnutrition. 21 patients were randomly assigned to parenteral nutrition (PN) group (10 patients) and control group (11 patients ). Patients in PN group were received parenteral nutritional support (PNS) for two weeks. The results showed: the level of serum free amino acids (SFAA) in 21 COPD patients with malnutrition were significantly lower than normal values (P<0.01 ). Two weeks later, the level of most SFAA in PN group increased (P<0. 01)significantly and did not change significantly in control group. This study indicaed that PNS was effective on these patients and the knowledge derived from this study would provids some rationale for the use of PNS in exacerbation of COPD patients with malnutrition.