大肠癌患者染色体不稳定性研究

Study on Chromosome Instability in Patients with Colorectal Carcinoma

对20例大肠癌患者和20例正常人外周血淋巴细胞染色体不稳定性及脆性部位的表达进行了研究，发现患者染色体裂隙、断裂及脆性部位表达率明显高于健康对照组，且脆性位点1q21、8q22在半数以上的病例中表达，并与癌基因同位或毗邻。说明大肠癌患者具有明显的染色体不稳定性特征，并提示其染色体不稳定性的增高可能与大肠癌患者的肿瘤遗传易感性增加有关。

The chromosome instability was investigated in 20 patients with colorectal carcinoma and 20 normal persons. The results indicated that the chromosome gaps, chromosome breakpoints and expression rate of fragile sites of the patients were markedly higher than those of the normal controls (P<0. 05 ).Fragile sites 1q21. 8q22 were expressed in more than half of the patients and were coincidented with oncogene respectively. It demonstrates the patients with colorectal carcincrna have significant higher chromosome instability, which might be related to the patients' higher genetic predisposition to tumorigenesis.