氯氮平与氯丙嗪所致静坐不能的临床对照研究

Clinical Comparative Study of Akathisia Caused by Clozapine and Chlorpromazine

对208例服用氯氮平（CZP）和206例服用氯丙嗪（CPZ）治疗的精神分裂症患者，进行了为期12周静坐不能的前瞻性临床对照研究．结果显示，CZP所致静坐不能的发生率明显低于CPZ，两组静坐不能患者静坐不能发生的时间，以及性别、年龄和病程无显著性差异，修改的Simpson锥体外系副反应量表的静坐不能评分、阴性症状量表（SANS）总分和异常不自主运动量表（AIMS）评分有显著性差异。对CZP和CPZ所致静坐不能的临床差异进行了讨论．

208 schizophrenic patients treated with clozapine and 206 treated with chlorpromazine as controls had been given prospective study on akathisia for 12 weeks. The results showed that the incidence of akathisia caused by clozapine was obviously lower than that by the controls ; sex, age and course of illness in the two groups had significant difference.The score of akathisia in the modified Simpson's Extrapyramidal Side Effects Rating Scale, the total scores of SANS and AIMS of patients with akathisia in the two groups had significant difference. It discussed the clinical difference of akathisia caused by clozapine and chlorpromazine.