单、双相情感性精神障碍父母育龄及胎次效应的比较研究

Comparison of Parental Age and Birth Order Effect in Monopolar and Bipolar Affective Disorder

应用Ｈａｌｄａｎｅ和Ｓｍｉｔｈ法，对１０５例双相、９４例单相躁狂症及３５例抑郁症进行父母育龄和胎次效应的比较研究．结果表明这三种情感障碍均有父母育龄和胎次的效应，但是双相及单相躁狂症与抑郁症的效应不同，初步提示情感性障碍的亚型间有遗传的异质性。

Using the method of Haldane and Smith, 105 cases of bipolar affective disorder, 94 cases of maul.1 and 35 cases of depression were compared on the effect of parental age and birth order. The results showed that the significant effect of parental age and birth order was detected in all the three types of affective disorder,but the effect in depression was different from that in mania and bipolar affective disorder. It suggests that genetic heterogeneity might exist in different types of affective disorder.