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Synthesis, Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging (MRI) Contrast Agents:Polylysine (Gd-DTPA/DOTA) with Pendent Galactose Moieties as Hepatocyte-targeting Groups 被引量:1

Synthesis, Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging (MRI) Contrast Agents:Polylysine (Gd-DTPA/DOTA) with Pendent Galactose Moieties as Hepatocyte-targeting Groups
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摘要 DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (<(DP)over bar> 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated. DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (<(DP)over bar> 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.
机构地区 WUHAN UNIV
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第2期157-160,共4页 中国化学快报(英文版)
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