A new variant of Knorr's pyrrole synthesis 被引量：1

A new variant of Knorr's pyrrole synthesis

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摘要 The reaction between ethyl 3-bromopyruvate and p-substituted anilines was found to involve the unexpected participation of acetone (solvent) forming N-aryl-5-methyl-pyrrole-3-carboxylates.The influence of p-substituents of aniline and the feasibility with other ketones were studied.N-aryl-indole-3-carboxylate (17) was synthesized successfully with this method.The unique character of p-methoxy-aniline in this reaction was discussed. The reaction between ethyl 3-bromopyruvate and p-substituted anilines was found to involve the unexpected participation of acetone (solvent) forming N-aryl-5-methyl-pyrrole-3-carboxylates.The influence of p-substituents of aniline and the feasibility with other ketones were studied.N-aryl-indole-3-carboxylate (17) was synthesized successfully with this method.The unique character of p-methoxy-aniline in this reaction was discussed.

作者 ZHANG,Yan JIANG,Yun-Zhen LIANG,Xiao-TianInstitute of Materia Medico,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China

出处《Chinese Journal of Chemistry》 SCIE CAS CSCD 1997年第4期371-378,共8页 中国化学（英文版）

关键词 Pyrrole synthesis ethyl 3-bromopyruvate ANILINES KETONES Pyrrole synthesis,ethyl 3-bromopyruvate,anilines,ketones

分类号 O621 [理学—有机化学]

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Chinese Journal of Chemistry

1997年第4期

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A new variant of Knorr's pyrrole synthesis 被引量：1

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