摘要
AIM To demonstrate the relationship between the ultrastructural changes of gastric mucosa and the syndrome differentiation in chronic gastritis. METHODS Sixteen chronic gastritis with Piweixuhan (PXG, the cold of insufficiency syndrome of the spleen and the stomach) and fifteen chronic gastritis with Ganweibuhe (GBG, incoordination syndrome of the liver and the stomach) were treated with Jianpiwenwei decoction (JWD, invigorating the spleen and warming the stomach) and Shuganhewei decoction (SHD, dispersing the stagnated Liver Qi and regulating the stomach) for three months. Before and after treatment, the gastroscopy was performed and gastric mucosa were collected from the lesser curvature of the antrum and the body in each patient, the ultrasections were made by the conventional method and observed and photographed under the JEM 100CX electron microscope. RESULTS The common ultrastructural anomalies of the two types in chronic gastritis were the plasmacyte infiltration and the lesions of the mucosal epithelial cells, chief cells and antral mucous cells with widely various degrees. But there was a obvious difference between the two types. In PXG, the predominant lesion of the chief cells was swelling of the mitochondria (Mi), while in GBG, of the chief cells and the plasmacytes was dilation of rough endoplasmic reticulum (rER). After treatment, the ultrastructural lesions in most cases were reverted to normal or improved obviously. CONCLUSION There was a close relationship between the ultrastructural changes of gastric mucosa and the syndrome differentiation of chronic gastritis. JWD and SHD could significantly improve the ultrastructural lesions of gastric mucosa.
