摘要
AIM To study the expression of gastrin in colorectal carcinoma tissues and its adjacent mucosa and discuss the action of gastrin on colorectal carcinoma. METHODS The gastrin expression in colorectal carcinoma tissues and its adjacent mucosa of 58 cases was examined by using immunohistochemical and immunoelectron microscopic technique. RESULTS Of the transitional mucosa (TM) of co_ lorectal carcinoma, nontypical dysplasia mucosa and carcinoma tissue, the positive rate of gastrin is 35 1%, 48 3% and 60 3% respectively, with an increasing trend ( P <0 05). The granules of protein A gold (PAG) of immunoelectron microscopy may be seen in different electro density secreting granules in carcinoma cells and intercellular spaces or on the surface of membrane microvillus. CONCLUSION The existence of gastrin in colorectal carcinoma tissue and its adjacent mucosa, and the carcinoma cells forming gastrin granules to release the gastrin may be one of the initial factors in occurrence and development of the carcinoma. Positive expression of gastrin in colorectal carcinoma tissues serves as a marker indicating a good differentiation.
