摘要
IM To compare the efficacy between a combined chemotherapy of ACNU (nimustine hydrochloride, brand name Nidran), a new nitrosourea agent, and a combined chemotherapy of methylCCNU for advanced gastric cancer.METHOD One hundred and three cases of advanced gastric cancer were randomly allocated into Group A (MeCCNU, 5FU and ADM) and Group B (ACNU, 5FU and ADM). The quality of life (QOL) questionnaire composed of 11 ordinal categorical items was studied in these patients.RESULTS In Group A there was no complete remission (CR) or partial remission (PR), while in Group B, although there was no CR, there were 8 PR (8/46 cases), denoting the response rate of 0% in Group A and 174% in Group B. The median survival time in Group A was 108 days and in Group B 112 days. Both groups tolerated well during the treatment and there were no serious adverse effects. QOL evaluations showed better psychological and physical feelings of tiredness in Group B than in Group A, and scores of face scale had more pleasant inclination.CONCLUSION ACNU combination is superior to MeCCNU combination for advanced gastric cancer.
作者
XIAO ShuDong1, LI DeHua1, ZHANG DeZhong1, SHEN MouJi1, ZHU XiaoTing1, HE GuiFen2, ZHAO TiPing2, XI LePing2, DENG XingCun3, WANG Min3, WANG XiuLing4, CHEN Qiang4, ZHANG YongPing4, YAO CuiLing5, BAO Ji
