睾丸活检对男性不育的诊断价值

The Diagnostic Value of Testis Biopsy in Male Infertility

45例男性不育患者共55份睾丸活检标本(有10例患者作了双侧活检)病理切片分析结果显示,睾丸生殖病理分类:正常6例,生精功能低下10例,其余39例分别为生精阻滞、纯支持细胞综合征、生精细胞脱落与管壁透明变性;精子发生障碍程度;正常6例,其余49例切片均见不同程度的生精障碍;用图像分析系统作形态学测量,发现生精障碍严重曲细精管直径变小,而基膜增厚。作者认为睾丸活检是确定无精子症病变环节的重要手段,是指导临床治疗、判断预后的可靠依据。图像分析的应用、实现了对睾丸病变的定量诊断,但在分析中要多点观察,遵循随机化、双盲原则。

Fifty-five samples of the biopsied testis tissues from 45 patients with male infertility were examined pathologically. 6 cases are normal while the rest shows various impairments includng hyposper-matogenesis, germinal arrest, Sertoli Cell Only Syndrome, sloughing of germ cells and tubular hyalinosis, The tubular diameter, cut area and the basal membrane of each slice were measured with a Color Medical Image Analysis System, It was found that the more severe the impairment. the shorter the tubular diameter and the thicker the basal membrane, The author suggested that testis biopsy be an important means by which physicians can study the mechanism of azoospermia and thus accurately choose therapy scheme according to the pathological findings. Image analysis makes quantitative diagnosis possible.