TMEM16A:钙激活氯通道研究进展

TMEM16A:progress in calcium activated chloride channels

钙激活氯通道(calcium-activated chloride channels,CaCCs)组织分布广泛,参与了众多生理过程,如感觉传导、神经和心肌兴奋性调节、腺体和上皮分泌等,甚至可能参与细胞分裂周期与细胞增殖。钙激活氯通道生理病理意义如此重要,但直到2008年才报道了跨膜蛋白16A(transmem-brane protein 16A,TMEM16A)为钙激活氯通道的分子基础,同时研究揭示TMEM16A在一些肿瘤组织中表达明显上调。该文即对钙激活氯通道的生理、病理学意义进行综述。

The Ca2＋activated Cl-channels（CaCCs） play a variety of physiological roles in many organs and tissues,including transduction of sensory stimuli,regulation of neuronal and cardiac excitability,and transepithelial Cl-secretion.In addition,CaCCs may be involved in the cell division cycle and cell proliferation.The molecular identity of CaCCs remained controversial until 2008 when TMEM16A,a member of the transmembrane protein 16 family,was identified as an important subunit of CaCCs.In this review,the physiological and pathophysiological roles of CaCCs are discussed.