脂肪栓塞综合征血液流变学的实验研究

AnExperimentalStudyofHemorrheologyinFatEmbolismSyndrome

目的：研究脂肪栓塞综合征血液流变学变化，以及氢化考地松对其影响．方法：实验动物随机分成对照、治疗及未治疗三组．治疗组和未治疗组采用油酸静脉注射诱发脂肪栓塞综合征，治疗组接受氢考治疗．观察三组动物死亡率、纤维蛋白原含量、血小板计数及血液流变学等指标．结果：未治疗组死亡率、纤维蛋白原含量及血粘因素等明显增高，血小板计数明显下降．结论：脂肪栓塞综合征血液多呈高粘滞状态，其原因与纤维蛋白原含量增高及血小板聚集有关．氢考可降低其血液粘滞度．

Aim:Tostudychangesofhemorrheologyinfatembolismsyndrome(FES)andtheefectofhydrocortisoneonhemorrheologyinFES.Methods:Theexperimentalrabbitswereselectedanddividedinto3groups:normalcontrol,treatedanduntreated.FESinthetreatedanduntreatedgroupswasinducedbyintravenousoleicacidandthetreatedgroupreceivedhydrocortisonetherepy.Mortalityrate,plateletcounts,fibrinogenconcentrationandhemorrheololgyindexwereobservedinthe3groups.Results:Itwasfoundthatmortalityrate,fibrinogenconcentration,bloodviscosityincreasedsignificantlyandplateletcountsdecreasedinuntreatedrabbits.Conclusion:HyperviscosityinFESisrelatedtobothincreaseoffibrinogenconcentrationandaggregationofplatelet.HydrocortisonecanreducebloodviscosityinFES.