普拉洛芬滴眼液治疗眼前节激光术后炎症反应的观察

Comparison study on the effectiveness of topical Pranoprofen for the inflammation after laser surgery of anterior segment

目的:评估普拉洛芬滴眼液在减轻眼前节激光术后,即激光虹膜周边切除术(LPI)和激光后囊切开术后炎症反应中的疗效。方法:选取60例60眼闭角型青光眼患者行LPI,60例60眼行激光后囊切开术,术后随机分为试验组和对照组,试验组包括行LPI患者30例30眼,行激光后囊切开术患者30例30眼,选用普拉洛芬滴眼液点眼。对照组包括行LPI患者30例30眼,行激光后囊切开术患者30例30眼,选用典必殊滴眼液点眼。观察指标为眼部疼痛、畏光、异物感、流泪等症状及充血、角膜上皮完整性、前房闪辉、前房浮游体等体征,以各项指标的综合评分评价其疗效。结果:试验组在术后1,3,7d综合评分与对照组比较,差异无显著性(P>0.05)。结论:普拉洛芬滴眼液应用于眼前节激光术后安全有效,可降低激素性高眼压的风险。

AIM：To evaluate the efficacy and safety of Pranoprofen eye drops in relieving reactions of postoperative inflammation of Nd：YAG laser to treat the disease of the anterior segment of the eye·METHODS：Totally 60 cases（60 eyes） with angle-closed glaucoma were performed laser peripheral iridotomy（LPI） and laser capsulotomy,then were randomly divided into two groups,experimental group and control group,30 cases（30 eyes） of each group.Pranoprofen and TobraDex eye drops,four times each day,were administered in experimental and control group respectively.All patients had been observed for 7 days.Ocular pain,photophobia,epiphora,conjunctival congestion,keratitis,aqueous humor flare were observed and recorded to calculate a comprehensive score to assess the curative effects·RESULTS：There was no significant difference in comprehensive score between the two groups at 1 day,3,7 days postoperatively（P〉0.05）·CONCLUSION：Pranoprofen eye drops have excellent efficacy and safety to control the inflammation after laser peripheral iridotomy and laser capsulotomy,it can decrease the danger of high intraocular pressure due to corticosteroid.