雷公藤在实验性弥漫性血管内凝血中对TXB_2/PGF_(1α)比值的影响

Study on Effects of Tripterygium on the Ratio Balance of TXB2 to 6-keto-PGF_(1a) in Plasma in Experimental Disseminated lntravascular Coagulation

用放射免疫分析法检测血浆血栓素 B_2(TXB_2)和6-酮-前列腺素 F_(1α)(6-keto-PGF_(1α))水平。结果表明:在弥漫性血管内凝血(DIC)模型中,TXB_2、6-keto-PGF_(1α)及 TXB_2/6-keto-PGF_(1α)比值显著上升(P<0.01,P<0.01,P<0.001),而布洛芬、雷公藤则能明显地降低 TXB_2/6-keto-PGF_(1α)比值(P<0.01,P<0.05),减轻内毒素 DIC 所致的多脏器损伤。提示雷公藤调节 TXB_2/6-keto-PGF_(1α)的平衡可能是其抗内毒素性 DIC 损伤的机制之一。

The SD rats were fed with Tripterygium(20mg/kg)or Ibuprofen(30mg/kg)everyday for one week Experimental models of endotoxin-induced disseminated intravascular coagulation(DIC)were made according to the method described by F Kunz,et al.The plasma levels of TXB2 and 6-keto-PGF_(1α)were measured with radioimmunoassay.It was found th at both the plasma levels of TXB_2 and 6-keto-PGF_(1α)and the ratio between them had increased significantly in the model group.After treated with Tripterygium or Ibuprofen,the experimental animals' plasma levels of TXP,2 and 6-keto-PGF_(1α) and the ratio between them had decreased markedly compared with model group.It was suggested that the treatment of Ibuprofen or Tripterygium could reduce the damage produced by DIC on experimental animals.Ohe of the mechanisms of the therapeutic effect of Triperygium on DIC might be attributed to the regulation of the ratio balance of TXB_2 to 6-keto- PGF_(1α)in plasma.