摘要
目的探讨放射总疗程对Ｌｅｗｉｓ肺癌治疗效果的影响。材料与方法将荷瘤Ｃ５７小鼠随机分入２，４，６，８天４个不同总疗程组中，每组取５个剂量点，分隔剂量为６～１５Ｇｙ，总照射剂量为２４～６０Ｇｙ。Ｌｅｗｉｓ肺癌的治疗效应用ＴＣＤ_(５０)（５０％肿瘤控制所需的外放射剂量）作为观察指标。结果随着疗程缩短，生存曲线左移，ＴＣＤ_(５０)值下降。疗程２～８天，ＴＣＤ_(５０)值分别为４８．７１Ｇｙ，３８．４５Ｇｙ，３４．８２Ｇｙ，２８．６０Ｇｙ，ＴＣＤ_(５０)值与疗程天数呈显著线性相关（Ｐ＜０．０５）。结论在总疗程时间为２～８天的范围内，缩短总疗程时间提高了Ｌｅｗｉｓ肺癌的治疗效果。
Purpose To study the effect of shorting overall treatment time on Lewis lung carcinoma. Materials and Methods TCD 50,defined as the total dose in controlling 50 % tumor,was used to measure the curative effects of Lewis lung carcinoma .The TCD50 assays were performed in four different overall treament schedules(2,4,6,8 days).The total dose of 24Gy～60Gy was given in 4 fractions with fractionated dose ranging from 6 Gy to 15 Gy,Resdults The survival curves moved left and the TCD 50 values decreased as the overall treatment time shorting from 8 days to 2 days.The value of TCD 50 was 48.71Gy, 38.45Gy,34.82Gy,28.60Gy for overall treatment time 8.6,4,2 days, respectively,There was line regression between TCD50 and overall treatment time. Conclusion The improvement of tumor curative effects was obtained as overall treatment time shorting from 8 days to 2 days.
出处
《中华放射肿瘤学杂志》
CSCD
1996年第4期255-258,共4页
Chinese Journal of Radiation Oncology
基金
"肺癌国家八五攻关课题"资助
