胃液氨含量与幽门螺杆菌相关性胃炎炎症程度的关系

RELATIONSHIP BETWEEN GASTRIC JUICE AMMONIA CONCENTRATIONS AND SEVERITY OF INFLAMMATION IN HELICOBACTER PYLORI ASSOCIATED GAS- TRITIS

为了探讨胃液氨含量与幽门螺杆菌（Ｈｐ）相关性胃炎炎症程度的关系，对３９例Ｈｐ（＋）及２３例Ｈｐ（－）慢性胃炎患者胃液氮含量进行测定，同时对其胃窦粘膜的炎症程度用中性粒细胞（ＰＭＮ）及单个核细胞（ＭＮ）计数方法予以评价。研究发现：Ｈｐ（＋）胃炎组胃液氨含量（８４．１０±３３．０７ｍｇ／Ｌ）显著高于Ｈｐ（－）胃炎组（２２．５９±１３．１２ｍｇ／Ｌ）（Ｐ＜０．０１），ＰＭＮ及ＭＮ计数在Ｈｐ（＋）胃炎组显著高于Ｈｐ（－）胃炎组，胃液氨含量与ＰＭＮ计数成正相关（ｒ＝０．４８，Ｐ＜０．０５），而与其ＭＮ计数无相关性。本研究表明胃液氨含量与Ｈｐ相关性胃炎的炎症程度关系密切，Ｈｐ的尿素酶产物－氨在Ｈｐ致胃粘膜损伤及炎症活动性中可能起着重要作用。

In order to investigate the relationship between gastric juice ammonia concentrations and severity of inflammation in helicobacter pylori (Hp ) associated gastritis. Gastric juice ammonia concen- trations were measured in 39 cases Hp -positive and 23 cases Hp -negative chronic gastritis patients .at the same time , the severity of inflammation in gastric untral mucosa was also evaluataed by the method of polymorphonuclear (PMN) and mononuclear (MN ) count. The results showed : gastric juice ammonia concentration in Hp -- positive gastritis group (84.10±33. 07mg/L)was significantly higher than that in the negative group (22. 59±13. 12mg/L) (P<0. 01). PMN and MN cell counting in Hp- positive group was also significantly higher than that in Hp -- negative group. There was a positive correlation between gastric ammonia concentrations and PMN count (r = 0. 48 , P < 0. 05 ) and no correlation was found be- tween gastric ammonia concentrations and MN count. The results indicate : Gastric juice ammonia con- centrations were correlative closely with the severity of gastric inflammation in Hp associated gastritis. The produts of urease -ammonia may play an important role in gastric mucosa injury and activity of in- flammation caused by Hp.