精神分裂症和抑郁症患者体感诱发电位的初步研究

Somatosensoryevokedpotentialinschizophreniaaneedpression:apreliminaryinvestigation

为观察精神分裂症和抑郁症患者体感诱发电位（ＳＥＰ）的变化，使用ＣＡ－１０００诱发电位叠加仪对４１例精神分裂症患者及２９例抑郁症患者ＳＥＰ进行观察，并与２５名正常人比较。结果显示，精神分裂症患者ＳＥＰ波型变异大，Ｐ２，Ｎ２及Ｐ３波潜伏期明显缩短，主波Ｐ２平均波幅较抑郁症和正常人组分别降低４０％及６３％，Ｎ１－Ｐ１，Ｐ２－Ｎ２及Ｐ３波波幅亦显著降低，与抑郁症和正常人组间均有显著或非常显著性差异。抑郁症患者Ｐ２波平均波幅比正常人组降低３０％，与正常人组有非常显著性差异。提示对ＳＥＰ作为精神科临床诊断和家系研究中易感素质筛选方面的生物学标记。

Theaimofthisstudywastoobservethevariationsofsomatosensoryevokedpotentials(SEP)inschizophreniaanddepression.In41schizophrenicand29depressivepatientsaccordingtothecriteriaofChineseCategoriesofMentalDisorders,2nded,theSEPhavebeenexaminedwithCA-1000summatorandcomparedwith25normaladults.Theresultsshowedthatthewaveformsintheschizophrenicsweremorevari-ablethanthoseofthenormalsubjects.TheSEPlatencyP2,N2andP3inschizophrenicsweresignificantlyshorterthanthoseofthedepressivepatientsandnormaladults(P<0.01).ItwasshowedthattheSEPaverageamplitudeP2inschizophrenicsreduced40%and63%re-spectivelyincomparisonwiththedepres-sivepatientsandnormaladults.TheSEPamplitudesN1-P1,P2-N2andP3inschizophrenicsweresignificantlylowerthanthoseofthedepressivepatientsandnormaladults(P<0.01),whiletheSEPaverageamplitudeP2inthedepressivepatientsreduced30%incom-parisonwithnormaladults(P<0.01).ThefurtherinvestigationshouldbeconductedinordertoproveSEPcouldserveasabiologicalmarkerindiagnosingthepsychoticdisordersandscreeningforthevulner-abilitiesamongtherelevantfamilymembers.