HBV感染者HCV的重叠感染关系研究

Superifection and mutual relation of hepatitis B and C virus

目的 研究HBV感染患者中HCV的重叠感染状况及其相互关系。 方法 采用ELISA法对767例HBV感染患者同步检测HBV和HCV血清标志物,对可疑HCV感染但抗HCV阴性和/或抗-HCV阳性患者血清,采用PCR法检测HCV-RNA。 结果 HCV重叠感染率为4.82％,且在各类乙肝患者中存在非常显著差异(P<0.01);HBV/HCV感染组重症肝炎的发生率显著高于非HCV感染组(P<0.01);HBV/HCV感染组HBsAg阳性率显著低于单纯HBV感染组(P<0.05);HBV/HCV感染组HCV-RNA阳性率显著低于单纯HCV感染组(P<0.05)。 结论 HCV重叠感染与乙肝患者的发病、病情加重及重症肝炎的发生相关;HCV可抑制或中止HBsAg携带状态,但这种作用远不如对病情的加重作用重要;同时HBV对HCV的复制亦存在抑制作用。

AIMS To study the superinfection of HBV and HCV and their mutual relation in patients with hepatitis B.METHODS Serum samples from 767 patients with hepatitis B were tested for HBV and HCV markers by ELISA. Sera from some patients doubtfully infected with HCV were detected for HCV-RNA by PCR technique.RESULTS The infective rate of HCV in 767 patients was 4.82%, and there were significant differences in different types of patients with hepatitis B(P<0.01), the incidence of fulminant hepatitis (FH) in the group of HBV and HCV superinfection was obviously higher than that in group of HBV infection only (F<0. 01). The positive rate of HBsAg in group of superinfection of HBV and HCV was significantly lower than that in group of single HBV infection ( P < 0. 05), and the positive rate of HCV-RNA in superinfection group was significantly lower than that in single HCV infection group (P<0.05).CONCLUSIONS The superinfection of HBV and HCV is closely associated with the attack, deteriortion of symptoms and the oc-curence of fulminant hepatitis. HCV could inhibit and stop the carry state of HBsAg, but it is far more important that HCV could deteriorate the symptoms. HBV also inhibit replication of HCV.