血清游离色氨酸浓度改变与亚临床肝性脑病

Serum Free Tryptophan Level in Patients with Subclinical Hepatic Encephatopathy

人血清中色氮酸以游离和结合两种形式存在。该文观察结果提示:游离色氨酸浓度增高与亚临床肝性脑病呈正相关(R>0.6)。

Aims: To evaluate the relationship between serum free tryptophan and subclinical hepatic encephalopathy. Methods: Serum free and total tryptophan were determined in 20 patients with liver cirrhosis complicated by subclinical hepatic encephalopathy (SHE) and 20 patients with cirrhosis without abnormal parameter of brain function. The diagnosis of SHE was based on brain-stem auditory evoked potential (BAEP) and other brain function tests. The control groups was consisted of 20 normal persons. Results: The mean serum tryptophan level of patients with SHE was 14.0±4.13μmol/L which is significantly higher than the levels of patients with cirrhosis without SHE(9. 0±3.32μmol/L, P<0.01) and normal controls (7.0±5.2μmol/L, P< 0.001). Conclusions: The determination of serum tryptophan level can serve as a useful parameter in diagnosis of SHE.