慢性阻塞性肺病患者血清透明质酸水平研究

Hyaluronic Acid Serum Levels in Patients With Chronic Obstructive Pulmonary Disease

采用放射免史疫法检测２８例慢性阻塞性肺病（ＣＯＰＤ）、２３例慢性肺心病及２１例正常对照血清透明质酸（ＨＡ）水平，结果显示：ＣＯＰＤ、肺心病组血清ＨＡ水平显著高于正常对照（Ｐ＜０．０１），肺心病组血清ＨＡ水平又高于ＣＯＰＤｔａ（Ｐ＜０．０１）。作者认为：血清ＨＡ水平可作为反映ＣＯＰＤ、肺心病病程进展的指标，对评价ＣＯＰ０、肺心病肺组织损害及估计预后有一定的临床意义。

Serum levels of hyaluronic acid(HA)were determinated using the method of radioimmunoassay in 28 patients with Chronic Obstructive Pulmonary Disease(COPD)and 23 patients with Chronic Cor pulmonale(CCP),21 cases as healthy control;HA concentrationsWere 91.67±12.08ng/ml、 197.96±67.98ng/ml、416.3± 154.69ng/ml in healthy control、COPD and CCP respectively.It was;bown that serum HA in patients with COPD or CCPwas significantly higher than those in healthy control.In addition,the levels of HA werehigher in patients with CCP than those in patients with COPD.There was significantly difference in the levels of serum HA between normal control and patients with COPD and CCP.These results indicated that serum HA may be the indicators in reflecting the severity ofCOPD and CCP.It was shown that determination of serum HA is better to the sensitive index for evalua-tion the degree of lung damage and expection the prognosis of COPD complicating with CCP.