Ⅰ、Ⅱ型精神分裂症病人血清LPO、wsFS、VE、GPX含量变化研究

Study on Content Changes of SerumLPO, wsFS, VE, GPX in I and IISchizophrenics

对７６例精神分裂症病人（Ⅰ型４７例，Ⅱ型２９例）进行了血清过氧化酯质（ＬＰＯ）、水溶性脂质过氧化物（ｗｓＦＳ）、维生素Ｅ（ＶＥ）、谷胱甘肽过氧化物酶（ＧＰＸ）的测定，并与５０名年龄相似的正常人相比较，发现精神分裂症病人血浴ＬＰＯ、ｗｓＦＳ含量较正常人显著增高，而ＶＥ、ＧＰＸ均低于正常人，其中Ⅱ型精神分裂症病人血清ＶＥ含量又较Ｉ型病人低。经氯丙嗪治疗后Ｉ型病人血清中上述含量有较大变化，而在Ⅱ型病人则没有明显变化。作者简单分析了自由基与Ⅰ、Ⅱ型精神分裂症的关系。

he authors deternumed the serum LPO, ws-FS, VE. GPX of 76 schizophrenics (including 47 Ischizophrening and 29 II schizophrenics ) and com-pared with those of the 50 normal controls at the similar age. The resuits showed that the content ofserum LPO and wsFS in the schizophrenics were re-markably higher than those in the normal controls,the content of VE and GPX were lower than in thecontrols . and among them the content of the serumVE in II schizophrenics were lower than that in Isehizophrenics . After treating with chlopromazine ,the contents above changed greatly in IIschizophrenics , but not in I schizophrenics. It alsoanalysed the relation between free radical and I, IIschizophrenia.