暴露疗法和氯丙咪嗪治疗强迫症四年随访

Four- Year Follow -up of ExposureTherapy and Chlorimipramine Treating Ob-session

用暴露疗法联合氯丙咪嗪或安慰剂双盲对照治疗４８例强迫症２０周，试验结束时氯丙咪嗪组疗效优于安慰剂。进行４年随访，至１年时氯丙咪嗪组疗效下降，安慰剂疗效维持。至第４年时两组差异消失，且８０％改善能维持。分析认为长程效果维持与实施暴露疗法有关。建议治疗强迫症用暴露疗法联合氯丙咪嗪。

orty-eight obsessions had been given double-blind contrast therapy for twenty weeks by expo-sure therapy combined with chlorimipramine orplacebo. The. results showed that the curative effectof the chlorimipramine group was better than of theplacebo group. We had four years of follow-up. Inthe first year, the curative effect of the chlorim-ipramine group decreased, of the placebo groupmaintained. In the fourth year, no difference ap-peared between the two groups, and 85% of thechanges maintained. It thinks the long-term effect maintenance was related to the implementation ofthe exposure therapy. It suggests to treat obsessionwith exposure therapy combiried with chlorim-ipramine.