摘要
hour urinary kallikrein excreation was measured(by fluorometry)in 300 children aged 10￣ 15 in Hanzhong. By comparison and retrospective study,the results showed:(1)in children with higher blood pressure(HBP)and positive family history of hypertension (FH+ ),the urinary kallikrein excreation was significantly lower than that in controls(P< 0.01).(2) the 12-hour urinary kallikrein excreation was negatively correlated with the SBP and DBP in the following up 3 times.(3)6-year retrospective review of blood pressure evolution showed that the blood pressure increased degree(△SBP) in children with lower urinary kallikrein excreation was much greater than that in those with higher one(P<0.01),and the percentiles or systolic blood pressure(△SBP)for children with lower urinary kallikrein mostly kept rising or kept up higher percentiles during the period. It is indicated that low urinary kallokrein may be a genetic marker to identify the children who are in danger or developing essential hypertension in future.
hour urinary kallikrein excreation was measured(by fluorometry)in 300 children aged 10￣ 15 in Hanzhong. By comparison and retrospective study,the results showed:(1)in children with higher blood pressure(HBP)and positive family history of hypertension (FH+ ),the urinary kallikrein excreation was significantly lower than that in controls(P< 0.01).(2) the 12-hour urinary kallikrein excreation was negatively correlated with the SBP and DBP in the following up 3 times.(3)6-year retrospective review of blood pressure evolution showed that the blood pressure increased degree(△SBP) in children with lower urinary kallikrein excreation was much greater than that in those with higher one(P<0.01),and the percentiles or systolic blood pressure(△SBP)for children with lower urinary kallikrein mostly kept rising or kept up higher percentiles during the period. It is indicated that low urinary kallokrein may be a genetic marker to identify the children who are in danger or developing essential hypertension in future.
