摘要
In order to investigate the cell origin of IL-6 in the disease of multiple myeloma(MM),the IL-6 levels in PBMC culture supernatants from MM and the healthy control were determined with 7TD1 hybridoma growth assay and the ability or MM cell and stroma cell to produce IL-6 was compared.The results showed IL-6 level in PBMC culture supernatants of MM group was evidently higher than that of the control group.Both MM cell and stroma cell could produce IL-6, but IL-6 amount produced by MM cell was 1.6 times as much as that by stroma cell(P<0.01).The results suggest that MM cell is the main cell to produce IL-6.
In order to investigate the cell origin of IL-6 in the disease of multiple myeloma(MM),the IL-6 levels in PBMC culture supernatants from MM and the healthy control were determined with 7TD1 hybridoma growth assay and the ability or MM cell and stroma cell to produce IL-6 was compared.The results showed IL-6 level in PBMC culture supernatants of MM group was evidently higher than that of the control group.Both MM cell and stroma cell could produce IL-6, but IL-6 amount produced by MM cell was 1.6 times as much as that by stroma cell(P<0.01).The results suggest that MM cell is the main cell to produce IL-6.
