蝮蛇抗栓酶与肝素抗凝治疗小儿肾病的疗效比较

Comparison of the Anticoagulant Therapeutic Effect of Svate III and Heparin In the Chil- dren with Idiopathic Nephrotic Syndrome

本文对60例小儿肾病患儿随机分为3组,蝮蛇抗栓酶治疗组,肝素治疗组,常规治疗组(对照组),结果总有效率分别为95％,90％,60％。蝮蛇抗栓酶组与对照组比较,差异有极显著性(P<0.01),肝素组与对照组比较,差异有显著性(P<0.05)。结果提示抗凝治疗对小儿肾病高凝状态有明显改善作用,能增加临床疗效。蝮蛇抗栓酶抗凝效果优于肝素。

Sixty cases of children with idiopathic nephrotic syndrome were divided into three groups: Svate I group,heparin group and conventional therapy group(the control group).The clinical remisson rates were 95%,90% and 60%,svate I group and heparin group were significantly higher than control group(P <0. 01 ,P<0. 05). The results suggested that the anticoagulant therapy may improve hypercoagulabity in idiopathic nephrotic syndrome and may increase the clinical effects. The results showed that svate III achieved more favorable outcome than heparin.