一氧化氮与阴茎勃起关系的实验研究

The Role of nitric Oxide in Canine Penile Erection

通过电刺激狗盆神经诱发阴茎勃起,选择硝普钠为一氧化氮(NO)的供体,研究了NO在阴茎勃起过程中的作用,并对其作用机理进行了初步探讨。实验结果支持海绵体平滑肌松弛为胆碱能神经和NANC神经所介导NO或其释放物质是阴茎勃起的主要NANC类神经递质的学说。

The role of nitric oxide and its relative factors (cGMP.cAMP, Methylene blue) was studied in canine erection induced by stimulating pelvic nerves.The results indicate that intracavernous injection of nitric oxide can evoke a penile tumescence,Which is similar to that of the neurostimulatioa.Methy lene blue can significantly inhibit the erectile response to both neurostimu latioa and sodium nitroprusside. The erectile response to intracavernous injection of cGM P was significantly better than that induced by cAM P .The study supports that Cholinergic and nonadrenergic nonchol inergic ( NANC ) neuroeffectors take part in penile erection,and nitric oxide may be one of chief penile erection,and nitric oxide may be one of chief NANC neurotransm itters.